Radiotracer synthesis from [11C]-iodomethane: a remarkably simple captive solvent method
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TECHNICAL NOTE Radiotracer Synthesis from [C]-Iodomethane: A Remarkably Simple Captive Solvent Method
A new method of [C]-methylation is described, which attains the goals of simplicity, high radiochemical yields, speed, versatility, and automation. A standard high performance liquid chromatography (HPLC) injection loop on a standard HPLC injection valve is loaded with a solution (80 mL) of precursor (0.3–1.0 mg) in dimethyl formamide (DMF) or dimethyl sulfoxide (DMSO) (1 base if required). At ...
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[11C]Methyl triflate ([11C]methyl trifluoromethanesulfonate) was formed in high yield when [11C]methyl iodide in a nitrogen carrier was passed at 200 degrees C through a column containing graphitized carbon impregnated with 50% by weight of silver triflate.
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ژورنال
عنوان ژورنال: Nuclear Medicine and Biology
سال: 2000
ISSN: 0969-8051
DOI: 10.1016/s0969-8051(00)00132-3